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Mendeley readers
Chapter title |
Analyses of HBV cccDNA Quantification and Modification
|
---|---|
Chapter number | 6 |
Book title |
Hepatitis B Virus
|
Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-6700-1_6 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6698-1, 978-1-4939-6700-1
|
Authors |
Yuchen Xia, Daniela Stadler, Chunkyu Ko, Ulrike Protzer |
Abstract |
Covalently closed circular DNA (cccDNA) serves as the transcriptional template of hepatitis B virus (HBV) replication in the nucleus of infected cells. It ensures the persistence of HBV even if replication is blocked. Immune-mediated killing of infected hepatocytes, cell division, or cytokine induced non-cytolytic degradation of cccDNA can induce the loss of cccDNA. For studies on HBV control, the analysis of cccDNA integrity and its exact quantification is very important. Here, we describe different methods for HBV cccDNA quantification and modification. |
Mendeley readers
The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 17 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 2 | 12% |
Student > Postgraduate | 2 | 12% |
Professor | 2 | 12% |
Other | 1 | 6% |
Student > Master | 1 | 6% |
Other | 1 | 6% |
Unknown | 8 | 47% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 3 | 18% |
Agricultural and Biological Sciences | 3 | 18% |
Immunology and Microbiology | 3 | 18% |
Medicine and Dentistry | 1 | 6% |
Unknown | 7 | 41% |