Chapter title |
TGF-β-Regulated MicroRNAs and Their Function in Cancer Biology.
|
---|---|
Chapter number | 21 |
Book title |
TGF-β Signaling
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-2966-5_21 |
Pubmed ID | |
Book ISBNs |
978-1-4939-2965-8, 978-1-4939-2966-5
|
Authors |
Yang, Pengyuan, Zhang, Yun, Markowitz, Geoffrey J, Guo, Xing, Wang, Xiao-Fan, Markowitz, Geoffrey J., Pengyuan Yang, Yun Zhang, Geoffrey J. Markowitz, Xing Guo, Xiao-Fan Wang |
Abstract |
The transforming growth factor-β (TGF-β) is known to regulate a large number of biological processes and is involved in various aspects of tumor development. Recent studies have shown that the biogenesis of miRNAs can be regulated by TGF-β signaling directly via Smad-dependent mechanisms and/or other unknown mechanisms, which may induce autoregulatory feedback loops in response to the activation of TGF-β signaling, influencing the fate of tumor cells. In this chapter, we summarize the currently described mechanisms underlying TGF-β's regulation of miRNA biogenesis, and the functional role of TGF-β-regulated miRNAs in tumor initiation, epithelial-mesenchymal transition, and tumor microenvironment modulation. Finally, we introduce methods to study TGF-β-regulated miRNAs and their functions in tumor progression and metastasis using an example of publication from our lab demonstrating the presence of a TGF-β-miR-34a-CCL22 signaling axis, which serves as a potent etiological pathway for the development of hepatocellular carcinoma venous metastases. |
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