Chapter title |
Gene Therapy of the Peripheral Nervous System: Celiac Ganglia
|
---|---|
Chapter number | 20 |
Book title |
Gene Therapy for Neurological Disorders
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-3271-9_20 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3270-2, 978-1-4939-3271-9
|
Authors |
Bradley Hammond, David L. Kreulen, Hammond, Bradley, Kreulen, David L. |
Abstract |
Gene therapy has played an integral role in advancing our understanding of the central nervous system. However, gene therapy techniques have yet to be widely utilized in the peripheral nervous system. Critical targets for gene therapy within the PNS are the neurons in sympathetic ganglia, which are the final pathway to end organs. Thus they are the most specific targets for organ-specific neuron modification. This presents challenges because neurons are not viscerotopically organized within the ganglia and therefore cannot be targeted by their location. However, organ-specific neurons have been identified in sympathetic ganglia of some species and this offers an opportunity for targeting and transducing neurons by way of their target. In fact, alterations in sympathetic neurons have had pathological effects, and transducing organ-specific sympathetic neurons offer an exciting opportunity to selectively modify sympathetic pathology. In this chapter, we describe a method to virally transduce the celiac ganglion (CG), a prevertebral sympathetic ganglion that innervates abdominal organs, with AAV serotypes 1 and 6; thereby, providing a potential avenue to modulate specific subsets of neurons within the celiac ganglion. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 4 | 36% |
Student > Ph. D. Student | 2 | 18% |
Professor > Associate Professor | 1 | 9% |
Student > Postgraduate | 1 | 9% |
Unknown | 3 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 3 | 27% |
Agricultural and Biological Sciences | 2 | 18% |
Biochemistry, Genetics and Molecular Biology | 1 | 9% |
Physics and Astronomy | 1 | 9% |
Veterinary Science and Veterinary Medicine | 1 | 9% |
Other | 0 | 0% |
Unknown | 3 | 27% |