Chapter title |
Viral Vector-Based Modeling of Neurodegenerative Disorders: Parkinson's Disease.
|
---|---|
Chapter number | 26 |
Book title |
Gene Therapy for Neurological Disorders
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-3271-9_26 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3270-2, 978-1-4939-3271-9
|
Authors |
Fischer, D Luke, Gombash, Sara E, Kemp, Christopher J, Manfredsson, Fredric P, Polinski, Nicole K, Duffy, Megan F, Sortwell, Caryl E, D. Luke Fischer, Sara E. Gombash, Christopher J. Kemp, Fredric P. Manfredsson, Nicole K. Polinski, Megan F. Duffy, Caryl E. Sortwell, Fischer, D. Luke, Gombash, Sara E., Kemp, Christopher J., Manfredsson, Fredric P., Polinski, Nicole K., Duffy, Megan F., Sortwell, Caryl E. |
Abstract |
Gene therapy methods are increasingly used to model Parkinson's disease (PD) in animals in an effort to test experimental therapeutics within a more relevant context to disease pathophysiology and neuropathology. We have detailed several criteria that are critical or advantageous to accurately modeling PD in a murine model or in a nonhuman primate. Using these criteria, we then evaluate approaches made to model PD using viral vectors to date, including both adeno-associated viruses and lentiviruses. Lastly, we comment on the consideration of aging as a critical factor for modeling PD. |
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