Chapter title |
Genome-Wide Co-Localization Screening of Nuclear Body Components Using a Fluorescently Tagged FLJ cDNA Clone Library.
|
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Chapter number | 9 |
Book title |
Nuclear Bodies and Noncoding RNAs
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Published in |
Methods in molecular biology, January 2015
|
DOI | 10.1007/978-1-4939-2253-6_9 |
Pubmed ID | |
Book ISBNs |
978-1-4939-2252-9, 978-1-4939-2253-6
|
Authors |
Tetsuro Hirose, Naoki Goshima |
Abstract |
Mammalian cell nuclei contain multiple granular structures, which are termed nuclear bodies. These structures are involved in various molecular events in the nucleus; they provide platforms for biogenesis of macromolecular complexes that are essential for gene expression, such as the ribosome and spliceosome; they act as reservoirs of various regulatory factors; and they are involved in the regulation of specific gene loci. Nuclear bodies are usually visualized by immunostaining for specific marker proteins. Although each type of nuclear body contains a distinct set of proteins, the protein components of most types of nuclear bodies remain to be identified. This chapter introduces a new approach to identify the protein components of specific types of nuclear bodies. |
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