Chapter title |
RNA Editing Deficiency in Neurodegeneration
|
---|---|
Chapter number | 3 |
Book title |
RNA Metabolism in Neurodegenerative Diseases
|
Published in |
Advances in neurobiology, January 2018
|
DOI | 10.1007/978-3-319-89689-2_3 |
Pubmed ID | |
Book ISBNs |
978-3-31-989688-5, 978-3-31-989689-2
|
Authors |
Ileana Lorenzini, Stephen Moore, Rita Sattler, Lorenzini, Ileana, Moore, Stephen, Sattler, Rita |
Abstract |
The molecular process of RNA editing allows changes in RNA transcripts that increase genomic diversity. These highly conserved RNA editing events are catalyzed by a group of enzymes known as adenosine deaminases acting on double-stranded RNA (ADARs). ADARs are necessary for normal development, they bind to over thousands of genes, impact millions of editing sites, and target critical components of the central nervous system (CNS) such as glutamate receptors, serotonin receptors, and potassium channels. Dysfunctional ADARs are known to cause alterations in CNS protein products and therefore play a role in chronic or acute neurodegenerative and psychiatric diseases as well as CNS cancer. Here, we review how RNA editing deficiency impacts CNS function and summarize its role during disease pathogenesis. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 28 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 7 | 25% |
Student > Bachelor | 3 | 11% |
Student > Postgraduate | 2 | 7% |
Student > Ph. D. Student | 1 | 4% |
Other | 1 | 4% |
Other | 2 | 7% |
Unknown | 12 | 43% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 8 | 29% |
Neuroscience | 4 | 14% |
Agricultural and Biological Sciences | 1 | 4% |
Psychology | 1 | 4% |
Computer Science | 1 | 4% |
Other | 2 | 7% |
Unknown | 11 | 39% |