Chapter title |
Pain Relief in Nonhuman Primate Models of Arthritis
|
---|---|
Chapter number | 28 |
Book title |
Inflammation
|
Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-6786-5_28 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6784-1, 978-1-4939-6786-5
|
Authors |
Michel P. M. Vierboom Ph.D., Elia Breedveld, Merei Keehnen, Rianne Klomp, Jaco Bakker, Michel P. M. Vierboom |
Editors |
Björn E. Clausen, Jon D. Laman |
Abstract |
Animal models of rheumatoid arthritis are important in the elucidation of etiopathogenic mechanisms of the disease and for the development of promising new therapies. Species specificity of new biological compounds and their mode of action preclude safety and efficacy testing in rodent models of disease. Nonhuman primates (NHP) can fill this niche and provide the only relevant model. Over the last two decades models of collagen-induced arthritis (CIA) were developed in the rhesus monkey and the common marmoset. However, NHP are higher-order animals and complex sentient beings. So especially in models where pain is an intricate part of the disease, analgesia needs to be addressed because of ethical considerations. In our model, a morphine-based pain relief was used that does not interfere with the normal development of disease allowing us to evaluate important mechanistic aspects of the arthritis. |
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Unknown | 1 | 100% |
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Members of the public | 1 | 100% |
Mendeley readers
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Unknown | 9 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 4 | 44% |
Student > Master | 2 | 22% |
Student > Ph. D. Student | 1 | 11% |
Professor | 1 | 11% |
Unknown | 1 | 11% |
Readers by discipline | Count | As % |
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Veterinary Science and Veterinary Medicine | 2 | 22% |
Medicine and Dentistry | 2 | 22% |
Biochemistry, Genetics and Molecular Biology | 1 | 11% |
Nursing and Health Professions | 1 | 11% |
Neuroscience | 1 | 11% |
Other | 0 | 0% |
Unknown | 2 | 22% |