Chapter 16 Nonclinical Safety and Toxicology

Chapter 17 In Vivo Target Validation Using Biological Molecules in Drug Development

Chapter 18 Implementation and Use of State-of-the-Art, Cell-Based In Vitro Assays

Chapter 19 Sources for Leads: Natural Products and Libraries

Chapter 20 Trends in Modern Drug Discovery

Chapter 21 Modeling and Simulation of In Vivo Drug Effects

Chapter 22 Translational In Vivo Models for Women’s Health: The Nonhuman Primate Endometrium—A Predictive Model for Assessing Steroid Receptor Modulators

Chapter 23 Using Cheminformatics in Drug Discovery

Chapter 25 High-Throughput Synthesis of Diverse Compound Collections for Lead Discovery and Optimization

Chapter 26 Pharmacokinetics in Drug Discovery: An Exposure-Centred Approach to Optimising and Predicting Drug Efficacy and Safety

Chapter 27 Functional Genomics in Pharmaceutical Drug Discovery.

Chapter 28 Emerging Target Families: Intractable Targets.

Chapter 29 Predictive In Vivo Models for Oncology

Chapter 30 New Compound Classes: Protein–Protein Interactions

Chapter 31 Translational In Vivo Models for Cardiovascular Diseases.