| Chapter title |
Nonhuman Primate Models of Ebola Virus Disease
|
|---|---|
| Chapter number | 20 |
| Book title |
Marburg- and Ebolaviruses
|
| Published in |
Current topics in microbiology and immunology, January 2017
|
| DOI | 10.1007/82_2017_20 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-968946-3, 978-3-31-968948-7
|
| Authors |
Richard S. Bennett, Louis M. Huzella, Peter B. Jahrling, Laura Bollinger, Gene G. Olinger, Lisa E. Hensley |
| Abstract |
Ebola virus disease (EVD) in humans is associated with four ebolaviruses: Ebola virus (EBOV), Sudan virus (SUDV), Bundibugyo virus (BDBV), and Taï Forest virus. To date, no documented cases of human disease have been associated with Reston virus. Here, we describe the nonhuman primate (NHP) models that currently serve as gold standards for testing ebolavirus vaccines and therapeutic agents and elucidating underlying mechanisms of pathogenesis. Although multiple models have been explored over the past 50 years, the predominance of published work has been performed in macaque models. This chapter will focus on the most commonly used models. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 31 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 23% |
| Student > Master | 4 | 13% |
| Student > Doctoral Student | 3 | 10% |
| Student > Ph. D. Student | 3 | 10% |
| Student > Bachelor | 2 | 6% |
| Other | 3 | 10% |
| Unknown | 9 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 26% |
| Immunology and Microbiology | 6 | 19% |
| Medicine and Dentistry | 3 | 10% |
| Veterinary Science and Veterinary Medicine | 2 | 6% |
| Psychology | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 10 | 32% |