Chapter title |
Reverse Genetics of Filoviruses
|
---|---|
Chapter number | 55 |
Book title |
Marburg- and Ebolaviruses
|
Published in |
Current topics in microbiology and immunology, January 2017
|
DOI | 10.1007/82_2017_55 |
Pubmed ID | |
Book ISBNs |
978-3-31-968946-3, 978-3-31-968948-7
|
Authors |
Thomas Hoenen, Janine Brandt, Yíngyún Caì, Jens H. Kuhn, Courtney Finch, Hoenen, Thomas, Brandt, Janine, Caì, Yíngyún, Kuhn, Jens H., Finch, Courtney |
Abstract |
Reverse genetics systems are used for the generation of recombinant viruses. For filoviruses, this technology has been available for more than 15 years and has been used to investigate questions regarding the molecular biology, pathogenicity, and host adaptation determinants of these viruses. Further, reporter-expressing, recombinant viruses are increasingly used as tools for screening for and characterization of candidate medical countermeasures. Thus, reverse genetics systems represent powerful research tools. Here we provide an overview of available reverse genetics systems for the generation of recombinant filoviruses, potential applications, and the achievements that have been made using these systems. |
X Demographics
Geographical breakdown
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Doctoral Student | 3 | 27% |
Researcher | 2 | 18% |
Student > Bachelor | 1 | 9% |
Student > Master | 1 | 9% |
Student > Ph. D. Student | 1 | 9% |
Other | 0 | 0% |
Unknown | 3 | 27% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 3 | 27% |
Immunology and Microbiology | 2 | 18% |
Veterinary Science and Veterinary Medicine | 1 | 9% |
Agricultural and Biological Sciences | 1 | 9% |
Nursing and Health Professions | 1 | 9% |
Other | 0 | 0% |
Unknown | 3 | 27% |