| Chapter title |
Filovirus Structural Biology: The Molecules in the Machine
|
|---|---|
| Chapter number | 16 |
| Book title |
Marburg- and Ebolaviruses
|
| Published in |
Current topics in microbiology and immunology, January 2017
|
| DOI | 10.1007/82_2017_16 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-968946-3, 978-3-31-968948-7
|
| Authors |
Robert N. Kirchdoerfer, Hal Wasserman, Gaya K. Amarasinghe, Erica Ollmann Saphire |
| Abstract |
In this chapter, we describe what is known thus far about the structures and functions of the handful of proteins encoded by filovirus genomes. Amongst the fascinating findings of the last decade is the plurality of functions and structures that these polypeptides can adopt. Many of the encoded proteins can play multiple, distinct roles in the virus life cycle, although the mechanisms by which these functions are determined and controlled remain mostly veiled. Further, some filovirus proteins are multistructural: adopting different oligomeric assemblies and sometimes, different tertiary structures to achieve their separate, and equally essential functions. Structures, and the functions they dictate, are described for components of the nucleocapsid, the matrix, and the surface and secreted glycoproteins. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 16 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 25% |
| Student > Master | 3 | 19% |
| Student > Bachelor | 3 | 19% |
| Unspecified | 1 | 6% |
| Student > Doctoral Student | 1 | 6% |
| Other | 2 | 13% |
| Unknown | 2 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 5 | 31% |
| Agricultural and Biological Sciences | 3 | 19% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 13% |
| Immunology and Microbiology | 2 | 13% |
| Unspecified | 1 | 6% |
| Other | 1 | 6% |
| Unknown | 2 | 13% |