Chapter title |
Challenges in the Development of Therapy for Dry Age-Related Macular Degeneration
|
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Chapter number | 15 |
Book title |
Retinal Degenerative Diseases
|
Published in |
Advances in experimental medicine and biology, January 2016
|
DOI | 10.1007/978-3-319-17121-0_15 |
Pubmed ID | |
Book ISBNs |
978-3-31-917120-3, 978-3-31-917121-0, 978-3-31-917120-3, 978-3-31-917121-0
|
Authors |
Cynthia X. Wei, Aixu Sun, Ying Yu, Qianyong Liu, Yue-Qing Tan, Isamu Tachibana, Hong Zeng, Ji-Ye Wei, Wei, Cynthia X., Sun, Aixu, Yu, Ying, Liu, Qianyong, Tan, Yue-Qing, Tachibana, Isamu, Zeng, Hong, Wei, Ji-Ye |
Abstract |
Dry age-related macular degeneration (AMD), a multifactorial progressive degenerative disease of the retinal photoreceptors, pigmented epithelium and Bruch's membrane/choroid in central retina, causes visual impairment in millions of elderly people worldwide. The only available therapy for this disease is the over-the-counter (OTC) multi-vitamins plus macular xanthophyll (lutein/zeaxanthin) which attempts to block the damages of oxidative stress and ionizing blue light. Therefore development of dry AMD prescribed treatment is a pressing unmet medical need. However, this effort is currently hindered by many challenges, including an incomplete understanding of the mechanism of pathogenesis that leads to uncertain targets, confounded by not yet validated preclinical models and the difficulty to deliver the drugs to the posterior segment of the eye. Additionally, with slow disease progression and a less than ideal endpoint measurement method, clinical trials are necessarily large, lengthy and expensive. Increased commitment to research and development is an essential foundation for dealing with these problems. Innovations in clinical trials with novel endpoints, nontraditional study designs and the use of surrogate diseases might shorten the study time, reduce the patient sample size and consequently lower the budget for the development of the new therapies for the dry AMD. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 43 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 8 | 19% |
Student > Master | 7 | 16% |
Researcher | 6 | 14% |
Student > Ph. D. Student | 5 | 12% |
Other | 3 | 7% |
Other | 6 | 14% |
Unknown | 8 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 21% |
Agricultural and Biological Sciences | 7 | 16% |
Biochemistry, Genetics and Molecular Biology | 5 | 12% |
Nursing and Health Professions | 5 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
Other | 5 | 12% |
Unknown | 10 | 23% |