Chapter title |
In-Depth Functional Diagnostics of Mouse Models by Single-Flash and Flicker Electroretinograms without Adapting Background Illumination.
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Chapter number | 82 |
Book title |
Retinal Degenerative Diseases
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Published in |
Advances in experimental medicine and biology, October 2015
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DOI | 10.1007/978-3-319-17121-0_82 |
Pubmed ID | |
Book ISBNs |
978-3-31-917120-3, 978-3-31-917121-0
|
Authors |
Tanimoto, Naoyuki, Michalakis, Stylianos, Weber, Bernhard H F, Wahl-Schott, Christian A, Hammes, Hans-Peter, Seeliger, Mathias W, Michalakis, S., Weber, Bernhard H. F., Wahl-Schott, C. A., Seeliger, Mathias W., Naoyuki Tanimoto, Stylianos Michalakis, Bernhard H. F. Weber, Christian A. Wahl-Schott, Hans-Peter Hammes, Mathias W. Seeliger, Wahl-Schott, Christian A. |
Abstract |
Electroretinograms (ERGs) are commonly recorded at the cornea for an assessment of the functional status of the retina in mouse models. Full-field ERGs can be elicited by single-flash as well as flicker light stimulation although in most laboratories flicker ERGs are recorded much less frequently than singleflash ERGs. Whereas conventional single-flash ERGs contain information about layers, i.e., outer and inner retina, flicker ERGs permit functional assessment of the vertical pathways of the retina, i.e., rod system, cone ON-pathway, and cone OFF-pathway, when the responses are evoked at a relatively high luminance (0.5 log cd s/m(2)) with varying frequency (from 0.5 to 30 Hz) without any adapting background illumination. Therefore, both types of ERGs complement an in-depth functional characterization of the mouse retina, allowing for a discrimination of an underlying functional pathology. Here, we introduce the systematic interpretation of the single-flash and flicker ERGs by demonstrating several different patterns of functional phenotype in genetic mouse models, in which photoreceptors and/or bipolar cells are primarily or secondarily affected. |
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