Chapter title |
Tauroursodeoxycholic Acid Protects Retinal Function and Structure in rd1 Mice
|
---|---|
Chapter number | 57 |
Book title |
Retinal Degenerative Diseases
|
Published in |
Advances in experimental medicine and biology, January 2016
|
DOI | 10.1007/978-3-319-17121-0_57 |
Pubmed ID | |
Book ISBNs |
978-3-31-917120-3, 978-3-31-917121-0
|
Authors |
Eric C. Lawson, Shagun K. Bhatia, Moon K. Han, Moe H. Aung, Vincent Ciavatta, Jeffrey H. Boatright, Machelle T. Pardue, Lawson, Eric C., Bhatia, Shagun K., Han, Moon K., Aung, Moe H., Ciavatta, Vincent, Boatright, Jeffrey H., Pardue, Machelle T. |
Abstract |
We explored the potential protective effects of tauroursodeoxycholic acid (TUDCA) on cone photoreceptor survival in a model of rapid retinal degeneration, the ß-Pde6 (rd1) (rd1) mouse model. We injected two strains of rd1 mice (B6.C3-Pde6b (rd1) Hps4(le)/J and C57BL/6J-Pde6b (rd1-2)/J mice) daily from postnatal day (P) 6 to P21 with TUDCA or vehicle. At P21, retinal function was evaluated with light-adapted electroretinography (ERG) and retinal structure was observed with plastic or frozen sections. TUDCA treatment partially preserved function and structure in B6.C3-Pde6b (rd1) Hps4(le)/J mice but only partially preserved structure in C57BL/6J-Pde6b (rd1-2)/J mice. Our results suggest a possible intervention for patients undergoing rapid retinal degeneration. |
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