Chapter title |
Interrelation Between Oxidative Stress and Complement Activation in Models of Age-Related Macular Degeneration
|
---|---|
Chapter number | 13 |
Book title |
Retinal Degenerative Diseases
|
Published in |
Advances in experimental medicine and biology, December 2015
|
DOI | 10.1007/978-3-319-17121-0_13 |
Pubmed ID | |
Book ISBNs |
978-3-31-917120-3, 978-3-31-917121-0
|
Authors |
Luciana M. Pujol-Lereis, Nicole Schäfer, Laura B. Kuhn, Bärbel Rohrer, Diana Pauly, Pujol-Lereis, Luciana M., Schäfer, Nicole, Kuhn, Laura B., Rohrer, Bärbel, Pauly, Diana |
Abstract |
Millions of individuals older than 50-years suffer from age-related macular degeneration (AMD). Associated with this multifactorial disease are polymorphisms of complement factor genes and a main environmental risk factor-oxidative stress. Until now the linkage between these risk factors for AMD has not been fully understood. Recent studies, integrating results on oxidative stress, complement activation, epidemiology and ocular pathology suggested the following sequence in AMD-etiology: initially, chronic oxidative stress results in modification of proteins and lipids in the posterior of the eye; these tissue alterations trigger chronic inflammation, involving the complement system; and finally, invasive immune cells facilitate pathology in the retina. Here, we summarize the results for animal studies which aim to elucidate this molecular interplay of oxidative events and tissue-specific complement activation in the eye. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 40 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 9 | 23% |
Student > Master | 6 | 15% |
Student > Doctoral Student | 4 | 10% |
Student > Bachelor | 3 | 8% |
Other | 3 | 8% |
Other | 6 | 15% |
Unknown | 9 | 23% |
Readers by discipline | Count | As % |
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Neuroscience | 3 | 8% |
Other | 3 | 8% |
Unknown | 12 | 30% |