Chapter title |
Retinal Degenerative Diseases
|
---|---|
Chapter number | 28 |
Book title |
Retinal Degenerative Diseases
|
Published in |
Advances in experimental medicine and biology, January 2016
|
DOI | 10.1007/978-3-319-17121-0_28 |
Pubmed ID | |
Book ISBNs |
978-3-31-917120-3, 978-3-31-917121-0
|
Authors |
Fogerty, Joseph, Denton, Kristin, Perkins, Brian D, Joseph Fogerty, Kristin Denton, Brian D. Perkins, Perkins, Brian D. |
Abstract |
The photoreceptor outer segment is a specialized primary cilium, and anchoring of the basal body at the apical membrane is required for outer segment formation. We hypothesized that basal body localization and outer segment formation would require the microtubule motor dynein 1 and analyzed the zebrafish cannonball and mike oko mutants, which carry mutations in the heavy chain subunit of cytoplasmic dynein 1 (dync1h1) and the p150(Glued) subunit of Dynactin (dctn1a). The distribution of Rab6, a player in the post-Golgi trafficking of rhodopsin, was also examined. Basal body docking was unaffected in both mutants, but Rab6 expression was reduced. The results suggest that dynein 1 is dispensable for basal body docking but that outer segment defects may be due to defects in post-Golgi trafficking. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 7 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 1 | 14% |
Student > Bachelor | 1 | 14% |
Student > Ph. D. Student | 1 | 14% |
Student > Master | 1 | 14% |
Researcher | 1 | 14% |
Other | 1 | 14% |
Unknown | 1 | 14% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 1 | 14% |
Psychology | 1 | 14% |
Chemistry | 1 | 14% |
Unknown | 1 | 14% |