↓ Skip to main content

Cadmium: From Toxicity to Essentiality

Overview of attention for book
Attention for Chapter 11: Cadmium in metallothioneins.
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (76th percentile)

Mentioned by

facebook
2 Facebook pages
wikipedia
2 Wikipedia pages

Citations

dimensions_citation
49 Dimensions

Readers on

mendeley
43 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Chapter title
Cadmium in metallothioneins.
Chapter number 11
Book title
Cadmium: From Toxicity to Essentiality
Published in
Metal ions in life sciences, February 2013
DOI 10.1007/978-94-007-5179-8_11
Pubmed ID
Book ISBNs
978-9-40-075178-1, 978-9-40-075179-8
Authors

Freisinger E, Vašák M, Eva Freisinger, Milan Vašák

Abstract

Metallothioneins (MTs) are low-molecular-mass cysteine-rich proteins with the ability to bind mono- and divalent metal ions with the electron configuration d ( 10 ) in form of metal-thiolate clusters. MTs are thought, among others, to play a role in the homeostasis of essential Zn(II) and Cu(I) ions. Besides these metal ions also Cd(II) can be bound to certain MTs in vivo, giving rise to the perception that another physiological role of MTs is in the detoxification of heavy metal ions. Substitution of the spectroscopically silent Zn(II) ions in metalloproteins by Cd(II) proved to be an indispensable tool to probe the Zn(II) sites in vitro. In this review, methods applied in the studies of structural and chemical properties of Cd-MTs are presented. The first section focuses on the physical basis of spectroscopic techniques such as electronic absorption, circular dichroism (CD), magnetic CD, X-ray absorption, and perturbed angular correlation of γ-rays spectroscopy, as well as mass spectrometry, and their applications to Cd-MTs from different organisms. The following is devoted to the discussion of metal binding affinities of Cd-MTs, cluster dynamics, the reactivity of bound Cd(II) ions with metal ion chelators and of thiolate ligands with alkylating and oxidizing agents. Finally, a brief summary of the known three-dimensional structures of Cd-MTs, determined almost exclusively by multinuclear NMR techniques, is presented. Besides Cd-MTs, the described methods can also be applied to the study of metal binding sites in other metalloproteins.

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 43 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 5%
Other 1 2%
Student > Bachelor 1 2%
Student > Master 1 2%
Professor > Associate Professor 1 2%
Other 0 0%
Unknown 37 86%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 1 2%
Agricultural and Biological Sciences 1 2%
Earth and Planetary Sciences 1 2%
Social Sciences 1 2%
Medicine and Dentistry 1 2%
Other 1 2%
Unknown 37 86%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 July 2013.
All research outputs
#744,038
of 3,622,349 outputs
Outputs from Metal ions in life sciences
#5
of 21 outputs
Outputs of similar age
#19,417
of 85,322 outputs
Outputs of similar age from Metal ions in life sciences
#1
of 1 outputs
Altmetric has tracked 3,622,349 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 21 research outputs from this source. They receive a mean Attention Score of 2.8. This one scored the same or higher as 16 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 85,322 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them