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Xenopus

Overview of attention for book
Cover of 'Xenopus'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Husbandry, General Care, and Transportation of Xenopus laevis and Xenopus tropicalis
  3. Altmetric Badge
    Chapter 2 Generation and Care of Xenopus laevis and Xenopus tropicalis Embryos
  4. Altmetric Badge
    Chapter 3 Methods for CRISPR/Cas9 Xenopus tropicalis Tissue-Specific Multiplex Genome Engineering
  5. Altmetric Badge
    Chapter 4 Targeted Genome Engineering in Xenopus Using the Transcription Activator-Like Effector Nuclease (TALEN) Technology
  6. Altmetric Badge
    Chapter 5 Genotyping of CRISPR/Cas9 Genome Edited Xenopus tropicalis
  7. Altmetric Badge
    Chapter 6 BATCH-GE: Analysis of NGS Data for Genome Editing Assessment
  8. Altmetric Badge
    Chapter 7 A Simple Knock-In System for Xenopus via Microhomology Mediated End Joining Repair
  9. Altmetric Badge
    Chapter 8 How to Generate Non-Mosaic CRISPR/Cas9 Mediated Knock-In and Mutations in F0 Xenopus Through the Host-Transfer Technique
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    Chapter 9 Targeted Electroporation in the CNS in Xenopus Embryos
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    Chapter 10 Conditional Chemogenetic Ablation of Photoreceptor Cells in Xenopus Retina
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    Chapter 11 Cancer Models in Xenopus tropicalis by CRISPR/Cas9 Mediated Knockout of Tumor Suppressors
  13. Altmetric Badge
    Chapter 12 CRISPR/Cas9 F0 Screening of Congenital Heart Disease Genes in Xenopus tropicalis
  14. Altmetric Badge
    Chapter 13 Quantitative Proteomics of Xenopus Embryos I, Sample Preparation
  15. Altmetric Badge
    Chapter 14 Quantitative Proteomics for Xenopus Embryos II, Data Analysis
  16. Altmetric Badge
    Chapter 15 Dye Electroporation and Imaging of Calcium Signaling in Xenopus Nervous System
  17. Altmetric Badge
    Chapter 16 X-FaCT: Xenopus-Fast Clearing Technique
  18. Altmetric Badge
    Chapter 17 Cell Cycle Analysis of the Embryonic Brain of Fluorescent Reporter Xenopus tropicalis by Flow Cytometry
  19. Altmetric Badge
    Chapter 18 Manipulating and Analyzing Cell Type Composition of the Xenopus Mucociliary Epidermis
  20. Altmetric Badge
    Chapter 19 Evaluating Blood Cell Populations in Xenopus Using Flow Cytometry and Differential Counts by Cytospin
  21. Altmetric Badge
    Chapter 20 Isolation and Culture of Amphibian (Xenopus laevis) Sub-Capsular Liver and Bone Marrow Cells
  22. Altmetric Badge
    Chapter 21 Isolation and Primary Culture Methods of Adult and Larval Myogenic Cells from Xenopus laevis
Attention for Chapter 12: CRISPR/Cas9 F0 Screening of Congenital Heart Disease Genes in Xenopus tropicalis
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Chapter title
CRISPR/Cas9 F0 Screening of Congenital Heart Disease Genes in Xenopus tropicalis
Chapter number 12
Book title
Xenopus
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-8784-9_12
Pubmed ID
Book ISBNs
978-1-4939-8783-2, 978-1-4939-8784-9
Authors

Deniz, Engin, Mis, Emily K, Lane, Maura, Khokha, Mustafa K, Engin Deniz, Emily K. Mis, Maura Lane, Mustafa K. Khokha

Abstract

In the US and Europe, birth defects are the leading cause of infant mortality. Among birth defects, Congenital Heart Disease (CHD) occurs in approximately 8 out of 1000 live births, affects 1.3 million newborns per year worldwide, and has the highest mortality rate. While there is evidence to indicate that CHD does have a genetic basis, most of the CHD burden remains unexplained genetically. Fortunately, new genomics technologies are enabling genetic analyses of CHD patients. Whole exome sequencing of trios as well as copy number variations assayed by high-density SNP arrays can now be obtained at high efficiency and relatively low cost. These efforts are identifying a number of sequence variations in patients with CHD, but only a small percentage have second unrelated alleles to validate them as disease causing. Importantly, most of these candidate genes do not have an identified molecular mechanism implicating them in cardiac development. Therefore, there is a pressing need to develop rapid functional assays to evaluate candidate genes for a role in cardiac development, and then to investigate the underlying developmental mechanisms. Most recently, the advent of CRISPR/Cas9 genome editing technology has greatly enhanced the ability to manipulate and observe the function of the genome in model systems and cell culture. Incorporating the power of a developmental system such as Xenopus tropicalis with the CRISPR/Cas9 system and the microscale imaging modality optical coherence tomography (OCT), the analysis of thousands of different genes in cardiac development becomes possible.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 22%
Researcher 3 17%
Student > Master 3 17%
Student > Ph. D. Student 3 17%
Professor 2 11%
Other 1 6%
Unknown 2 11%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 28%
Medicine and Dentistry 4 22%
Computer Science 1 6%
Agricultural and Biological Sciences 1 6%
Business, Management and Accounting 1 6%
Other 2 11%
Unknown 4 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2019.
All research outputs
#10,584,157
of 16,534,657 outputs
Outputs from Methods in molecular biology
#3,343
of 9,574 outputs
Outputs of similar age
#168,783
of 279,827 outputs
Outputs of similar age from Methods in molecular biology
#1
of 1 outputs
Altmetric has tracked 16,534,657 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,574 research outputs from this source. They receive a mean Attention Score of 2.7. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,827 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them