| Chapter title |
eIF3 Regulation of Protein Synthesis, Tumorigenesis, and Therapeutic Response.
|
|---|---|
| Chapter number | 9 |
| Book title |
Eukaryotic Transcriptional and Post-Transcriptional Gene Expression Regulation
|
| Published in |
Methods in molecular biology, January 2017
|
| DOI | 10.1007/978-1-4939-6518-2_9 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-6516-8, 978-1-4939-6518-2
|
| Authors |
Ji-Ye Yin, Zizheng Dong, Jian-Ting Zhang |
| Editors |
Narendra Wajapeyee, Romi Gupta |
| Abstract |
Translation initiation is the rate-limiting step of protein synthesis and highly regulated. Eukaryotic initiation factor 3 (eIF3) is the largest and most complex initiation factor consisting of 13 putative subunits. A growing number of studies suggest that eIF3 and its subunits may represent a new group of proto-oncogenes and associates with prognosis. They regulate translation of a subset of mRNAs involved in many cellular processes including proliferation, apoptosis, DNA repair, and cell cycle. Therefore, unveiling the mechanisms of eIF3 action in tumorigenesis may help identify attractive targets for cancer therapy. Here, we describe a series of methods used in the study of eIF3 function in regulating protein synthesis, tumorigenesis, and cellular response to therapeutic treatments. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 7 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 3 | 43% |
| Professor | 1 | 14% |
| Student > Bachelor | 1 | 14% |
| Student > Master | 1 | 14% |
| Student > Ph. D. Student | 1 | 14% |
| Other | 0 | 0% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 4 | 57% |
| Nursing and Health Professions | 2 | 29% |
| Agricultural and Biological Sciences | 1 | 14% |