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Chapter title |
A High-Throughput Screen for Inhibitors of the Hsp90-Chaperone Machine
|
---|---|
Chapter number | 7 |
Book title |
Chaperones
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Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-7477-1_7 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7476-4, 978-1-4939-7477-1
|
Authors |
Jason Davenport, Lakshmi Galam, Robert L. Matts |
Abstract |
Hsp90 has emerged as a key chemotherapeutic target for the development of drugs for the treatment of cancer and neurodegenerative diseases. The shortcomings of many of the Hsp90 inhibitors that have made it to clinical trials have bolstered the need to identify new lead compounds with superior properties. Here, we describe a high-throughput screen for the identification of Hsp90 inhibitors based on the refolding of thermally denatured firefly luciferase. |
Mendeley readers
The data shown below were compiled from readership statistics for 1 Mendeley reader of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Lecturer | 1 | 100% |
Readers by discipline | Count | As % |
---|---|---|
Unknown | 1 | 100% |