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Mendeley readers
Chapter title |
Determination of Hsp90 Activity Through Activation of Glucocorticoid Receptors in Yeast
|
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Chapter number | 14 |
Book title |
Chaperones
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Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-7477-1_14 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7476-4, 978-1-4939-7477-1
|
Authors |
Michael Reidy |
Abstract |
Heat shock protein 90 (Hsp90) is an essential regulator of cellular function through activation of so-called client proteins. Hsp90 is currently a target for potential anti-cancer therapeutics. Assaying for defects in Hsp90 using budding yeast (Saccharomyces cerevisiae) is possible and efficient due to the high conservation between the human and yeast Hsp90 systems. Here, we present a method for the determination of Hsp90 activity indirectly through the activation of exogenously expressed glucocorticoid receptor, a natural client protein of Hsp90. |
Mendeley readers
The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 5 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Unspecified | 1 | 20% |
Researcher | 1 | 20% |
Student > Master | 1 | 20% |
Unknown | 2 | 40% |
Readers by discipline | Count | As % |
---|---|---|
Unspecified | 1 | 20% |
Biochemistry, Genetics and Molecular Biology | 1 | 20% |
Agricultural and Biological Sciences | 1 | 20% |
Unknown | 2 | 40% |