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Mendeley readers
Attention Score in Context
Chapter title |
Quantifying Caspase-1 Activity in Murine Macrophages
|
---|---|
Chapter number | 14 |
Book title |
Inflammation and Cancer
|
Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-7568-6_14 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7567-9, 978-1-4939-7568-6
|
Authors |
Dave Boucher, Amy Chan, Connie Ross, Kate Schroder |
Abstract |
The caspase-1 protease is a core component of multiprotein inflammasome complexes, which play a critical role in regulating the secretion of mature, bioactive pro-inflammatory cytokines interleukin (IL)-1β and IL-18. The activity of caspase-1 is often measured indirectly, by monitoring cleavage of cellular caspase-1 substrates, processing of caspase-1 itself, or by quantifying cell death. Here we describe methods for eliciting caspase-1 activity in murine macrophages, via activation of the NLRP3, NAIP/NLRC4 or AIM2 inflammasomes. We then describe a simple fluorogenic assay for directly quantifying cellular caspase-1 activity. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 3 | 33% |
United Kingdom | 2 | 22% |
Ireland | 2 | 22% |
Denmark | 1 | 11% |
Unknown | 1 | 11% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 56% |
Scientists | 4 | 44% |
Mendeley readers
The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 13 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Doctoral Student | 3 | 23% |
Student > Ph. D. Student | 3 | 23% |
Student > Master | 2 | 15% |
Researcher | 2 | 15% |
Student > Bachelor | 1 | 8% |
Other | 1 | 8% |
Unknown | 1 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 38% |
Immunology and Microbiology | 3 | 23% |
Biochemistry, Genetics and Molecular Biology | 2 | 15% |
Agricultural and Biological Sciences | 2 | 15% |
Unknown | 1 | 8% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2018.
All research outputs
#4,692,555
of 23,016,919 outputs
Outputs from Methods in molecular biology
#1,360
of 13,165 outputs
Outputs of similar age
#102,993
of 442,344 outputs
Outputs of similar age from Methods in molecular biology
#122
of 1,498 outputs
Altmetric has tracked 23,016,919 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,165 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 442,344 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 1,498 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.