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Chapter title |
Assays for Identifying Inducers of the Antimicrobial Peptide LL-37
|
---|---|
Chapter number | 19 |
Book title |
Antimicrobial Peptides
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Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-6737-7_19 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6735-3, 978-1-4939-6737-7
|
Authors |
Frank Nylén, Peter Bergman, Gudmundur H. Gudmundsson, Birgitta Agerberth, Nylén, Frank, Bergman, Peter, Gudmundsson, Gudmundur H., Agerberth, Birgitta |
Abstract |
One promising approach to meet the growing problem of antibiotic resistance is to modulate host defense mechanisms, i.e., host-directed therapy (HDT), in the fight against infections. Induction of endogenous antimicrobial peptides (AMPs) via small molecular compounds, such as 1,25-dihydroxyvitamin D3 or phenylbutyrate, could provide one such HDT-based approach.We have developed a cell-based screening assay for the identification of novel compounds with the capacity to induce AMP expression and here follows the detailed protocol. |
Mendeley readers
The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 8 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 2 | 25% |
Librarian | 1 | 13% |
Other | 1 | 13% |
Professor | 1 | 13% |
Student > Bachelor | 1 | 13% |
Other | 2 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 2 | 25% |
Biochemistry, Genetics and Molecular Biology | 2 | 25% |
Medicine and Dentistry | 2 | 25% |
Immunology and Microbiology | 1 | 13% |
Arts and Humanities | 1 | 13% |
Other | 0 | 0% |