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Chapter title |
The Interaction of Antimicrobial Peptides with the Membrane and Intracellular Targets of Staphylococcus aureus Investigated by ATP Leakage, DNA-Binding Analysis, and the Expression of a LexA-Controlled Gene, recA
|
---|---|
Chapter number | 21 |
Book title |
Antimicrobial Peptides
|
Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-6737-7_21 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6735-3, 978-1-4939-6737-7
|
Authors |
Sanne Gottschalk, Line Elnif Thomsen, Gottschalk, Sanne, Thomsen, Line Elnif |
Abstract |
The analysis of how antimicrobial peptides (AMPs) interact with bacterial membranes and intracellular targets is important for our understanding of how these molecules affect bacteria. Increased knowledge may aid the design of AMPs that work on their target bacterium without inducing bacterial resistance. Here, we describe different methods to investigate the mode of action of peptides against the Gram-positive bacterium Staphylococcus aureus. ATP leakage analysis can be used to evaluate the ability of AMPs to perturb bacteria. DNA-binding and SOS response induction can be analyzed to investigate intracellular targets. |
Mendeley readers
The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 12 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Doctoral Student | 2 | 17% |
Student > Bachelor | 2 | 17% |
Researcher | 2 | 17% |
Professor | 1 | 8% |
Lecturer | 1 | 8% |
Other | 2 | 17% |
Unknown | 2 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 4 | 33% |
Immunology and Microbiology | 2 | 17% |
Biochemistry, Genetics and Molecular Biology | 1 | 8% |
Medicine and Dentistry | 1 | 8% |
Chemistry | 1 | 8% |
Other | 1 | 8% |
Unknown | 2 | 17% |