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Protein Reviews

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Attention for Chapter 57: P2Y 1 Receptors – Properties and Functional Activities
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Chapter title
P2Y 1 Receptors – Properties and Functional Activities
Chapter number 57
Book title
Protein Reviews
Published in
Advances in experimental medicine and biology, January 2017
DOI 10.1007/5584_2017_57
Pubmed ID
Book ISBNs
978-9-81-107610-7, 978-9-81-107611-4
Authors

Jolanta Barańska, Rafał Czajkowski, Paweł Pomorski

Abstract

In this chapter we try to show a comprehensive image of current knowledge of structure, activity and physiological role of the P2Y1 purinergic receptor. The structure, distribution and changes in the expression of this receptor are summarized, as well as the mechanism of its signaling activity by the intracellular calcium mobilization. We try to show the connection between the components of its G protein activation and cellular or physiological effects, starting from changes in protein phosphorylation patterns and ending with such remote effects as receptor-mediated apoptosis. The special emphasis is put on the role of the P2Y1 receptor in cancer cells and neuronal plasticity. We concentrate on the P2Y1 receptor, it is though impossible to completely abstract from other aspects of nucleotide signaling and cross-talk with other nucleotide receptors is here discussed. Especially, the balance between P2Y1 and P2Y12 receptors, sharing the same ligand but signaling through different pathways, is presented.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 30%
Professor 1 10%
Other 1 10%
Student > Bachelor 1 10%
Researcher 1 10%
Other 1 10%
Unknown 2 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 20%
Neuroscience 2 20%
Medicine and Dentistry 1 10%
Agricultural and Biological Sciences 1 10%
Chemistry 1 10%
Other 0 0%
Unknown 3 30%