| Chapter title |
Unconventional Protein Secretion
|
|---|---|
| Chapter number | 2 |
| Book title |
Unconventional Protein Secretion
|
| Published in |
Methods in molecular biology, January 2016
|
| DOI | 10.1007/978-1-4939-3804-9_2 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-3802-5, 978-1-4939-3804-9
|
| Authors |
Ng, Fanny, Tang, Bor Luen, Fanny Ng, Bor Luen Tang |
| Editors |
Andrea Pompa, Francesca De Marchis |
| Abstract |
All eukaryotic cells secrete a range of proteins in a constitutive or regulated manner through the conventional or canonical exocytic/secretory pathway characterized by vesicular traffic from the endoplasmic reticulum, through the Golgi apparatus, and towards the plasma membrane. However, a number of proteins are secreted in an unconventional manner, which are insensitive to inhibitors of conventional exocytosis and use a route that bypasses the Golgi apparatus. These include cytosolic proteins such as fibroblast growth factor 2 (FGF2) and interleukin-1β (IL-1β), and membrane proteins that are known to also traverse to the plasma membrane by a conventional process of exocytosis, such as α integrin and the cystic fibrosis transmembrane conductor (CFTR). Mechanisms underlying unconventional protein secretion (UPS) are actively being analyzed and deciphered, and these range from an unusual form of plasma membrane translocation to vesicular processes involving the generation of exosomes and other extracellular microvesicles. In this chapter, we provide an overview on what is currently known about UPS in animal cells. |
X Demographics
Geographical breakdown
| Country | Count | As % |
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| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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|---|---|---|
| United States | 1 | 3% |
| Unknown | 31 | 97% |
Demographic breakdown
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|---|---|---|
| Student > Ph. D. Student | 10 | 31% |
| Researcher | 5 | 16% |
| Student > Postgraduate | 3 | 9% |
| Student > Doctoral Student | 2 | 6% |
| Professor > Associate Professor | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 11 | 34% |
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|---|---|---|
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| Medicine and Dentistry | 1 | 3% |
| Chemistry | 1 | 3% |
| Engineering | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 11 | 34% |