| Chapter title |
Role and Characterization of Synuclein-γ Unconventional Protein Secretion in Cancer Cells
|
|---|---|
| Chapter number | 15 |
| Book title |
Unconventional Protein Secretion
|
| Published in |
Methods in molecular biology, January 2016
|
| DOI | 10.1007/978-1-4939-3804-9_15 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-3802-5, 978-1-4939-3804-9
|
| Authors |
Caiyun Liu, Like Qu, Chengchao Shou Ph.D., M.D., Chengchao Shou |
| Editors |
Andrea Pompa, Francesca De Marchis |
| Abstract |
Synuclein-γ (SNCG), the third member of synuclein family, is implicated in both neurodegenerative diseases and cancer. Overexpression of SNCG in cancer cells is linked to tumor progression and chemoresistance. Without any known signal sequence required for conventional protein secretion, SNCG is elevated in the serum of cancer patients and the medium of cultured cancer cells. SNCG actively secretes from cancer cells and extracellular SNCG promotes malignant phenotypes of cancer cells. Here, we describe methods for the characterization of SNCG as an unconventional secretion protein from cancer cells and investigation of the effect of extracellular SNCG on the phenotypes of cancer cells. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 13 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 5 | 38% |
| Student > Ph. D. Student | 2 | 15% |
| Other | 1 | 8% |
| Student > Master | 1 | 8% |
| Professor > Associate Professor | 1 | 8% |
| Other | 1 | 8% |
| Unknown | 2 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 6 | 46% |
| Biochemistry, Genetics and Molecular Biology | 2 | 15% |
| Agricultural and Biological Sciences | 1 | 8% |
| Environmental Science | 1 | 8% |
| Unknown | 3 | 23% |