| Chapter title |
Mesenchymal Stem Cells for Osteochondral Tissue Engineering.
|
|---|---|
| Chapter number | 3 |
| Book title |
Mesenchymal Stem Cells
|
| Published in |
Methods in molecular biology, January 2016
|
| DOI | 10.1007/978-1-4939-3584-0_3 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-3582-6, 978-1-4939-3584-0
|
| Authors |
Johnathan Ng, Jonathan Bernhard, Gordana Vunjak-Novakovic |
| Editors |
Massimiliano Gnecchi |
| Abstract |
Mesenchymal stem cells (MSC) are of major interest in regenerative medicine, as they are easily harvested from a variety of sources (including bone marrow and fat aspirates) and they are able to form a range of mesenchymal tissues, in vitro and in vivo. We focus here on the use of MSCs for engineering of cartilage, bone, and complex osteochondral tissue constructs, using protocols that replicate some aspects of natural mesodermal development. For engineering of human bone, we discuss some of the current advances, and highlight the use of perfusion bioreactors for supporting anatomically exact human bone grafts. For engineering of human cartilage, we discuss the limitations of current approaches, and highlight engineering of stratified, mechanically functional human cartilage interfaced with bone by mesenchymal condensation of MSCs. Taken together, current advances enable engineering of physiologically relevant bone, cartilage and osteochondral composites, and physiologically relevant studies of osteochondral development and disease. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 40 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 28% |
| Student > Master | 4 | 10% |
| Researcher | 4 | 10% |
| Student > Doctoral Student | 3 | 8% |
| Professor | 3 | 8% |
| Other | 5 | 13% |
| Unknown | 10 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 9 | 23% |
| Engineering | 7 | 18% |
| Medicine and Dentistry | 4 | 10% |
| Materials Science | 3 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
| Other | 5 | 13% |
| Unknown | 11 | 28% |