Chapter title |
The STIM-Orai Pathway: The Interactions Between STIM and Orai
|
---|---|
Chapter number | 4 |
Book title |
Store-Operated Ca²⁺ Entry (SOCE) Pathways
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-3-319-57732-6_4 |
Pubmed ID | |
Book ISBNs |
978-3-31-957731-9, 978-3-31-957732-6
|
Authors |
Marc Fahrner, Rainer Schindl, Martin Muik, Isabella Derler, Christoph Romanin |
Abstract |
A primary Ca(2+) entry pathway in non-excitable cells is established by the Ca(2+) release-activated Ca(2+) channels. Their two limiting molecular components include the Ca(2+)-sensor protein STIM1 located in the endoplasmic reticulum and the Orai channel in the plasma membrane. STIM1 senses the luminal Ca(2+) content, and store depletion induces its oligomerization into puncta-like structures, thereby triggering coupling to as well as activation of Orai channels. A C-terminal STIM1 domain is assumed to couple to both C- and N-terminal, cytosolic strands of Orai, accomplishing gating of the channel. Here we highlight the inter- and intramolecular steps of the STIM1-Orai signaling cascade together with critical sites of the pore structure that accomplishes Ca(2+) permeation. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 3 | 14% |
Unspecified | 2 | 10% |
Student > Ph. D. Student | 2 | 10% |
Student > Bachelor | 1 | 5% |
Professor | 1 | 5% |
Other | 2 | 10% |
Unknown | 10 | 48% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 6 | 29% |
Unspecified | 2 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
Agricultural and Biological Sciences | 1 | 5% |
Immunology and Microbiology | 1 | 5% |
Other | 0 | 0% |
Unknown | 10 | 48% |