Chapter title |
The Role of Mitochondria in the Activation/Maintenance of SOCE: The Contribution of Mitochondrial Ca2+ Uptake, Mitochondrial Motility, and Location to Store-Operated Ca2+ Entry
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Chapter number | 16 |
Book title |
Store-Operated Ca²⁺ Entry (SOCE) Pathways
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Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-3-319-57732-6_16 |
Pubmed ID | |
Book ISBNs |
978-3-31-957731-9, 978-3-31-957732-6
|
Authors |
Roland Malli, Wolfgang F. Graier |
Abstract |
In most cell types, the depletion of internal Ca(2+) stores triggers the activation of Ca(2+) entry. This crucial phenomenon is known since the 1980s and referred to as store-operated Ca(2+) entry (SOCE). With the discoveries of the stromal-interacting molecules (STIMs) and the Ca(2+)-permeable Orai channels as the long-awaited molecular constituents of SOCE, the role of mitochondria in controlling the activity of this particular Ca(2+) entry pathway is kind of buried in oblivion. However, the capability of mitochondria to locally sequester Ca(2+) at sites of Ca(2+) release and entry was initially supposed to rule SOCE by facilitating the Ca(2+) depletion of the endoplasmic reticulum and removing entering Ca(2+) from the Ca(2+)-inhibitable channels, respectively. Moreover, the central role of these organelles in controlling the cellular energy metabolism has been linked to the activity of SOCE. Nevertheless, the exact molecular mechanisms by which mitochondria actually determine SOCE are still pretty obscure. In this essay we describe the complexity of the mitochondrial Ca(2+) uptake machinery and its regulation, molecular components, and properties, which open new ways for scrutinizing the contribution of mitochondria to SOCE. Moreover, data concerning the variability of the morphology and cellular distribution of mitochondria as putative determinants of SOCE activation, maintenance, and termination are summarized. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 17 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 3 | 18% |
Researcher | 3 | 18% |
Student > Postgraduate | 3 | 18% |
Student > Master | 2 | 12% |
Other | 1 | 6% |
Other | 2 | 12% |
Unknown | 3 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 6 | 35% |
Agricultural and Biological Sciences | 3 | 18% |
Neuroscience | 2 | 12% |
Medicine and Dentistry | 1 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Other | 0 | 0% |
Unknown | 4 | 24% |