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SiRNA Delivery Methods

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Cover of 'SiRNA Delivery Methods'

Table of Contents

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    Book Overview
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    Chapter 1 Synthesis and Conjugation of Small Interfering Ribonucleic Neutral SiRNNs.
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    Chapter 2 Liver-Targeted SiRNA Delivery Using Biodegradable Poly(amide) Polymer Conjugates
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    Chapter 3 SiRNA Delivery Methods
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    Chapter 4 Highly Efficient SiRNA Delivery Mediated by Cationic Helical Polypeptides and Polypeptide-Based Nanosystems
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    Chapter 5 Disulfide-Bridged Cleavable PEGylation of Poly- l -Lysine for SiRNA Delivery
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    Chapter 6 Preparation of a Cyclic RGD: Modified Liposomal SiRNA Formulation for Use in Active Targeting to Tumor and Tumor Endothelial Cells
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    Chapter 7 A Multifunctional Envelope-Type Nano Device Containing a pH-Sensitive Cationic Lipid for Efficient Delivery of Short Interfering RNA to Hepatocytes In Vivo
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    Chapter 8 Bioreducible Poly(Beta-Amino Ester)s for Intracellular Delivery of SiRNA
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    Chapter 9 Preparation of Polyion Complex Micelles Using Block Copolymers for SiRNA Delivery
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    Chapter 10 Delivery of Small Interfering RNAs to Cells via Exosomes.
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    Chapter 11 Dendrimer Nanovectors for SiRNA Delivery.
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    Chapter 12 Chitosan Nanoparticles for SiRNA Delivery In Vitro
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    Chapter 13 Non-Covalently Functionalized of Single-Walled Carbon Nanotubes by DSPE-PEG-PEI for SiRNA Delivery
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    Chapter 14 SiRNA In Vivo-Targeted Delivery to Murine Dendritic Cells by Oral Administration of Recombinant Yeast.
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    Chapter 15 TLR9-Targeted SiRNA Delivery In Vivo.
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    Chapter 16 Aptamer-MiRNA Conjugates for Cancer Cell-Targeted Delivery.
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    Chapter 17 Method for Confirming Cytoplasmic Delivery of RNA Aptamers.
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    Chapter 18 Hapten-Binding Bispecific Antibodies for the Targeted Delivery of SiRNA and SiRNA-Containing Nanoparticles
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    Chapter 19 Stable Delivery of CCR5-Directed shRNA into Human Primary Peripheral Blood Mononuclear Cells and Hematopoietic Stem/Progenitor Cells via a Lentiviral Vector.
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    Chapter 20 Hepatic Delivery of Artificial Micro RNAs Using Helper-Dependent Adenoviral Vectors.
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    Chapter 21 Intravascular AAV9 Administration for Delivering RNA Silencing Constructs to the CNS and Periphery.
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    Chapter 22 Efficient Gene Suppression in Dorsal Root Ganglia and Spinal Cord Using Adeno-Associated Virus Vectors Encoding Short-Hairpin RNA.
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    Chapter 23 Synthetic SiRNA Delivery: Progress and Prospects.
Attention for Chapter 4: Highly Efficient SiRNA Delivery Mediated by Cationic Helical Polypeptides and Polypeptide-Based Nanosystems
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Chapter title
Highly Efficient SiRNA Delivery Mediated by Cationic Helical Polypeptides and Polypeptide-Based Nanosystems
Chapter number 4
Book title
SiRNA Delivery Methods
Published in
Methods in molecular biology, January 2016
DOI 10.1007/978-1-4939-3112-5_4
Pubmed ID
Book ISBNs
978-1-4939-3111-8, 978-1-4939-3112-5
Authors

Lichen Yin, Nan Zheng, Jianjun Cheng, Yin, Lichen, Zheng, Nan, Cheng, Jianjun

Abstract

RNA interference (RNAi) mediated by small interfering RNA (SiRNA) has recently emerged as a potent machinery in regulating gene expression at the post-translation step. Despite its efficiency and specificity, the biggest hurdle against its wide application is the safe and effective delivery of the SiRNA cargo into target cells. Here, we describe the highly effective SiRNA delivery mediated by the cationic helical polypeptides and polypeptide-based nanosystems both in vitro and in vivo via oral administration.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 5 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 40%
Student > Ph. D. Student 1 20%
Unknown 2 40%
Readers by discipline Count As %
Agricultural and Biological Sciences 2 40%
Chemistry 1 20%
Unknown 2 40%