Chapter title |
Th1-Inducing Agents in Prophylaxis and Therapy for Paracoccidioidomycosis
|
---|---|
Chapter number | 12 |
Book title |
Vaccines for Invasive Fungal Infections
|
Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-7104-6_12 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7103-9, 978-1-4939-7104-6
|
Authors |
Thiago Aparecido da Silva, Fabrício Freitas Fernandes, Taise Natali Landgraf, Ademílson Panunto-Castelo, Maria Cristina Roque-Barreira |
Editors |
Markus Kalkum, Margarita Semis |
Abstract |
Adjuvants and immunomodulatory molecules could be included in the treatment of P. brasiliensis infection. In this context, we reported that the therapeutic and/or prophylactic administration of Th1-inducing agents, such as immunomodulatory lectins and adjuvants, was able to provide protection against experimental paracoccidioidomycosis. Then, we described the protocols to investigate the effect of immunomodulatory agents on the course of P. brasiliensis infection. In this sense, we detailed the measurement of fungal burden and cytokine production, and the histopathological analysis used to evaluate the most effective administration regime. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Professor | 1 | 50% |
Student > Bachelor | 1 | 50% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 1 | 50% |
Medicine and Dentistry | 1 | 50% |