Chapter title |
Vaccine Design
|
---|---|
Chapter number | 21 |
Book title |
Vaccine Design
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-3387-7_21 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3385-3, 978-1-4939-3387-7
|
Authors |
Monteiro, Mario A, Mario A. Monteiro |
Editors |
Sunil Thomas |
Abstract |
Clostridium difficile vaccines composed of surface polysaccharides (PSs) have the potential to simultaneously control infection and colonization levels in humans. Hot water-phenol treatment of C. difficile biomass can extricate water-soluble PS-I and PS-II; and water- and phenol-soluble PS-III. C. difficile vaccines based on PS-II have attracted the most attention due its facile purification and ubiquitous expression by C. difficile ribotypes. Anti PS-II antibodies recognize both C. difficile vegetative cell and sporulating preparations and confer protection against C. difficile infection in a mouse model. The design of such an efficacious C. difficile PS-II conjugate vaccine is described here. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 4 | 27% |
Student > Bachelor | 3 | 20% |
Student > Doctoral Student | 2 | 13% |
Student > Ph. D. Student | 1 | 7% |
Professor | 1 | 7% |
Other | 2 | 13% |
Unknown | 2 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 3 | 20% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 13% |
Biochemistry, Genetics and Molecular Biology | 2 | 13% |
Computer Science | 1 | 7% |
Veterinary Science and Veterinary Medicine | 1 | 7% |
Other | 4 | 27% |
Unknown | 2 | 13% |