Chapter title |
DNA Vaccines: A Strategy for Developing Novel Multivalent TB Vaccines.
|
---|---|
Chapter number | 18 |
Book title |
Vaccine Design
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-3387-7_18 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3385-3, 978-1-4939-3387-7
|
Authors |
Jaemi S. Chu, Daniel O. Villarreal, David B. Weiner |
Editors |
Sunil Thomas |
Abstract |
Multivalent DNA vaccines that are delivered by electroporation (EP) through muscle tissue provide a novel method for eliciting immunity against tuberculosis (TB) as well as a broad range of diseases including HIV and cancers. Proper plasmid construction containing suitable protective TB antigens capable of evoking desired vaccine-induced responses would lead to the appropriate induction of both humoral and cellular immunity. DNA vaccines are safe and of low cost in comparison to traditional vaccines while also providing potentially effective prophylactic or therapeutic modalities against currently untreatable diseases. Here, we describe the steps for developing a rational multivalent TB DNA vaccine delivered with intramuscular EP in mice. |
X Demographics
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United States | 2 | 100% |
Demographic breakdown
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Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
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Unknown | 11 | 100% |
Demographic breakdown
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Researcher | 3 | 27% |
Student > Ph. D. Student | 2 | 18% |
Other | 1 | 9% |
Lecturer | 1 | 9% |
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Other | 1 | 9% |
Unknown | 2 | 18% |
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Economics, Econometrics and Finance | 1 | 9% |
Other | 1 | 9% |
Unknown | 2 | 18% |